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Article

IL12B and IL23R gene SNPs in Japanese psoriasis.

Immunogenetics - 1 Nov 2013

Oka Akira, Mabuchi Tomotaka, Ikeda Shigaku, Terui Tadashi, Haida Yuko, Ozawa Akira, Yatsu Keisuke, Kulski Jerzy K, Inoko Hidetoshi

Abstract excerpt

Psoriasis is a common human skin disease whereby abnormal production of inflammatory mediators is believed to play an important role in its pathogenesis. The IL12B gene, which encodes the shared IL-12p40 subunit in two cytokines, IL-12 and IL-23, and the IL23R gene, which encodes a subunit of the receptor for IL-23, were identified as psoriasis-susceptibility genetic factors in recent candidate gene and...

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PMID: 23955419
DOI: 10.1007/s00251-013-0721-x

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