Article
Polymorphic analysis of the matrix metalloproteinase-9 gene and susceptibility to sporadic abdominal aortic aneurysm.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Jun 2007
Armani Chiara, Curcio Michele, Barsotti Maria Chiara, Santoni Tatiana, Di Stefano Rossella, Dell'omodarme Matteo, Brandi Maria Luisa, Ferrari Mauro, Scatena Fabrizio, Carpi Angelo, Balbarini Alberto
Abstract excerpt
Abdominal aortic aneurysm (AAA) has a multifactorial aetiology and the importance of genetic components is getting increasing interest. Alteration in the structure of the vascular extracellular matrix has been described in AAA. Matrix metalloproteinases (MMPs) degrade extracellular matrix proteins which alter the vessel wall stability. We evaluated two different polymorphisms, a CA repeat and a cytosine to...
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