Article
Polymorphisms of the matrix metalloproteinase 9 gene and abdominal aortic aneurysm.
The British journal of surgery - 1 Oct 2008
Smallwood L, Allcock R, van Bockxmeer F, Warrington N, Palmer L J, Iacopetta B, Golledge J, Norman P E
Abstract excerpt
BACKGROUND: Increased matrix metalloproteinase (MMP) 9 activity has been implicated in the formation of abdominal aortic aneurysm (AAA). The aim was to explore the association between potentially functional variants of the MMP-9 gene and AAA. METHODS: The -1562C > T and -1811A > T variants of the MMP-9 gene were genotyped in 678 men with an AAA (at least 30 mm in diameter) and 659 control subjects (aortic...
Topics
- Aged
- Aged, 80 and over
- Aortic Aneurysm, Abdominal
- Case-Control Studies
- Genotype
- Humans
- Male
- Matrix Metalloproteinase 9
- Polymorphism, Genetic