Article
The study of t-PA, u-PA and PAI-1 genes polymorphisms in patients with abdominal aortic aneurysm.
Molecular biology reports - 1 May 2014
Oszajca Katarzyna, Wroński Konrad, Janiszewska Grażyna, Bieńkiewicz Małgorzata, Bartkowiak Jacek, Szemraj Janusz
Abstract excerpt
The most important feature of abdominal aortic aneurysm (AAA) pathogenesis is an enzymatic degradation of elastic lamellae and extracellular matrix proteins particularly with participation of matrix metalloproteinases. Plasmin, which is responsible for the dissolution of fibrin in blood vessels, plays also a key role in the cascade for activation of the metalloproteinases. The purpose of this study was to...
Topics
- Adult
- Aged
- Alleles
- Aortic Aneurysm, Abdominal
- Case-Control Studies
- Female
- Gene Frequency
- Genotype
- Humans
- INDEL Mutation
- Male
- Middle Aged
- Plasminogen Activator Inhibitor 1
- Polymorphism, Genetic
- Polymorphism, Single Nucleotide