Tissue inhibitor of metalloproteinase-1 (TIMP-1) polymorphisms in a Caucasian population with abdominal aortic aneurysm.

doi:10.1007/s00268-007-9209-x

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Article

Tissue inhibitor of metalloproteinase-1 (TIMP-1) polymorphisms in a Caucasian population with abdominal aortic aneurysm.

World journal of surgery - 1 Nov 2007

Hinterseher Irene, Krex Dietmar, Kuhlisch Eberhard, Schmidt Karl G, Pilarsky Christian, Schneiders Wolfgang, Saeger Hans D, Bergert Hendrik

Abstract excerpt

BACKGROUND: The formation of a sporadic abdominal aortic aneurysm (AAA) is explained by the remodeling of the extracellular matrix (ECM) and breakdown of structural components of the vascular wall. Matrix metalloproteinases are the principal matrix-degrading proteases and are known to play a major role in the remodeling of the extracellular matrix in arterial vessels. Their activity is controlled by tissue...

Topics

Aged
Aged, 80 and over
Aortic Aneurysm, Abdominal
Female
Gene Frequency
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Tissue Inhibitor of Metalloproteinase-1
White People

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Open in PubMed

Identifiers

PMID: 17899257
DOI: 10.1007/s00268-007-9209-x

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