Article
Tissue inhibitor of metalloproteinase-1 (TIMP-1) polymorphisms in a Caucasian population with abdominal aortic aneurysm.
World journal of surgery - 1 Nov 2007
Hinterseher Irene, Krex Dietmar, Kuhlisch Eberhard, Schmidt Karl G, Pilarsky Christian, Schneiders Wolfgang, Saeger Hans D, Bergert Hendrik
Abstract excerpt
BACKGROUND: The formation of a sporadic abdominal aortic aneurysm (AAA) is explained by the remodeling of the extracellular matrix (ECM) and breakdown of structural components of the vascular wall. Matrix metalloproteinases are the principal matrix-degrading proteases and are known to play a major role in the remodeling of the extracellular matrix in arterial vessels. Their activity is controlled by tissue...
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