Article
Matrix metalloproteinase-9 coding sequence single-nucleotide polymorphisms in caucasians with intracranial aneurysms.
Neurosurgery - 1 Jul 2004
Krex Dietmar, Kotteck Kerstin, König Inke R, Ziegler Andreas, Schackert Hans K, Schackert Gabriele
Abstract excerpt
OBJECTIVE: There are several lines of evidence suggesting that matrix metalloproteinases (MMPs), particularly MMP-9, are involved in the pathogenesis of intracranial aneurysms. Some studies have demonstrated that genetic variants in the promoter region of the MMP-9 gene are associated with aneurysms. We performed a case-control study to investigate whether single-nucleotide polymorphisms (SNPs) within the coding...
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