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Article

MYH mutations are rare in prostate cancer.

Journal of cancer research and clinical oncology - 1 Jun 2007

Shin Eyun-Jung, Chappell Edward, Pethe Vaijayanti, Hersey Karen, van der Kwast Theodore, Fleshner Neil, Bapat Bharati

Abstract excerpt

PURPOSE: Oxidative stress is considered a risk factor for prostate cancer development and is associated with the production of reactive oxygen species (ROS). The base excision repair gene MYH protects against ROS-mediated damage to DNA. Inherited MYH mutations predispose to colorectal adenomas and cancer. A compromised base-excision repair function due to defective MYH may contribute to prostate carcinogenesis....

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Source

Identifiers

PMID: 17219200
DOI: 10.1007/s00432-006-0181-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

MYH mutations are rare in prostate cancer.PMID 17219200Read ↗

Association between biallelic and monoallelic germline MYH gene mutations and colorectal cancer risk.Semantic proximity Read ↗

The prevalence of Lynch syndrome (DNA mismatch repair protein deficiency) in patients with primary localized prostate cancerSemantic proximity Read ↗

Role of MYH polymorphisms in sporadic colorectal cancer in China: a case-control, population-based study.Semantic proximity Read ↗

MYH Y165C and G382D mutations in hepatocellular carcinoma and cholangiocarcinoma patients.Semantic proximity Read ↗

Microsatellite stable colorectal cancers in clinically suspected hereditary nonpolyposis colorectal cancer patients without vertical transmission of disease are unlikely to be caused by biallelic germline mutations in MYH.Semantic proximity Read ↗

Reduced expression of the DNA glycosylase gene MUTYH is associated with an increased number of somatic mutations via a reduction in the DNA repair capacity in prostate adenocarcinoma.Semantic proximity Read ↗

Frequent mismatch-repair defects link prostate cancer to Lynch syndrome.Semantic proximity Read ↗

Germline MYH mutations in a clinic-based series of Canadian multiple colorectal adenoma patients.Semantic proximity Read ↗

Germ-line mutations in mismatch repair genes associated with prostate cancer.Semantic proximity Read ↗

Population-based study of the association of variants in mismatch repair genes with prostate cancer risk and outcomes.Semantic proximity Read ↗

Increased frequency of disease-causing MYH mutations in colon cancer families.Semantic proximity Read ↗

Proportion and phenotype of MYH-associated colorectal neoplasia in a population-based series of Finnish colorectal cancer patients.Semantic proximity Read ↗

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