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Increased frequency of disease-causing MYH mutations in colon cancer families.

Carcinogenesis - 1 Nov 2006

Peterlongo Paolo, Mitra Nandita, Sanchez de Abajo Ana, de la Hoya Miguel, Bassi Chiara, Bertario Lucio, Radice Paolo, Glogowski Emily, Nafa Khedoudja, Caldes Trinidad, Offit Kenneth, Ellis Nathan A

Abstract excerpt

The genetic factors that cause clustering of colorectal cancers (CRCs) other than mutations in the mismatch repair (MMR) genes are not well understood. Clustering in families who lack MMR gene mutations may be attributable to low-penetrance mutations. Hypothetically, mono-allelic MYH mutations could contribute to the risk of CRC in these families. Using Fisher's exact test and logistic regression, we compared the...

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PMID: 16774938
DOI: 10.1093/carcin/bgl093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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