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Article

Frequent mismatch-repair defects link prostate cancer to Lynch syndrome.

BMC urology - 24 Mar 2016

Dominguez-Valentin Mev, Joost Patrick, Therkildsen Christina, Jonsson Mats, Rambech Eva, Nilbert Mef

Abstract excerpt

BACKGROUND: A possible role for prostate cancer in Lynch syndrome has been debated based on observations of mismatch-repair defective tumors and reports of an increased risk of prostate cancer in mutation carriers. Potential inclusion of prostate cancer in the Lynch syndrome tumor spectrum is relevant for family classification, risk estimates and surveillance recommendations in mutation carriers. METHODS: We used...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27013479
DOI: 10.1186/s12894-016-0130-1
PMCID: PMC4806412

Genes

MLH1
MSH2
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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