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Article

Population-based study of the association of variants in mismatch repair genes with prostate cancer risk and outcomes.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2010

Langeberg Wendy J, Kwon Erika M, Koopmeiners Joseph S, Ostrander Elaine A, Stanford Janet L

Abstract excerpt

BACKGROUND: Mismatch repair (MMR) gene activity may be associated with prostate cancer risk and outcomes. This study evaluated whether single nucleotide polymorphisms (SNP) in key MMR genes are related to prostate cancer outcomes. METHODS: Data from two population-based case-control studies of pr...

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Topics

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Share to Adenosine Triphosphatases
Share to DNA Mismatch Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair Enzymes

Share to Mismatch Repair Endonuclease PMS2

Share to MutL Protein Homolog 1

Share to MutS Homolog 2 Protein

Share to Neoplasm Recurrence, Local

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Source

Open in PubMed Open full text

Identifiers

PMID: 20056646
DOI: 10.1158/1055-9965.EPI-09-0800
PMCID: PMC2825566

Genes

MLH1
MSH2
PMS2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-20056646-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

Related research

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Population-based study of the association of variants in mismatch repair genes with prostate cancer risk and outcomes.PMID 20056646Read ↗

Genetic Analysis Reveals the Prognostic Significance of the DNA Mismatch Repair Gene MSH2 in Advanced Prostate CancerSemantic proximity Read ↗

Mutational spectrum of DNA damage and mismatch repair genes in prostate cancerSemantic proximity Read ↗

Mismatch repair deficiency may be common in ductal adenocarcinoma of the prostate.Semantic proximity Read ↗

Genetic Polymorphism of Mismatch Repair Genes and Susceptibility to Prostate Cancer.Semantic proximity Read ↗

High prevalence of mismatch repair deficiency in prostate cancers diagnosed in mismatch repair gene mutation carriers from the colon cancer family registry.Semantic proximity Read ↗

A study of molecular signals deregulating mismatch repair genes in prostate cancer compared to benign prostatic hyperplasia.Semantic proximity Read ↗

Common variants in mismatch repair genes associated with increased risk of sperm DNA damage and male infertility.Semantic proximity Read ↗

Genetic variation in DNA repair genes and prostate cancer risk: results from a population-based study.Semantic proximity Read ↗

Up-regulation of mismatch repair genes MSH6, PMS2 and MLH1 parallels development of genetic instability and is linked to tumor aggressiveness and early PSA recurrence in prostate cancerSemantic proximity Read ↗

Complex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer.Semantic proximity Read ↗

A prospective prostate cancer screening programme for men with pathogenic variants in mismatch repair genes (IMPACT): initial results from an international prospective studySemantic proximity Read ↗

Germ-line mutations in mismatch repair genes associated with prostate cancer.Semantic proximity Read ↗

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