Article
Germ-line mutations in mismatch repair genes associated with prostate cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 2009
Grindedal Eli Marie, Møller Pål, Eeles Ros, Stormorken Astrid Tenden, Bowitz-Lothe Inger Marie, Landrø Stefan Magnus, Clark Neal, Kvåle Rune, Shanley Susan, Maehle Lovise
Abstract excerpt
Genetic predisposition to prostate cancer includes multiple common variants with a low penetrance (single nucleotide polymorphisms) and rare variants with higher penetrance. The mismatch repair (MMR) genes MLH1, MSH2, MSH6, and PMS2 are associated with Lynch syndrome where colon and endometrial c...
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