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Article

A talin mutant that impairs talin-integrin binding in platelets decelerates αIIbβ3 activation without pathological bleeding.

Blood - 24 Apr 2014

Stefanini Lucia, Ye Feng, Snider Adam K, Sarabakhsh Kasra, Piatt Raymond, Paul David S, Bergmeier Wolfgang, Petrich Brian G

Abstract excerpt

Tight regulation of integrin affinity is critical for hemostasis. A final step of integrin activation is talin binding to 2 sites within the integrin β cytoplasmic domain. Binding of talin to a membrane-distal NPxY sequence facilitates a second, weaker interaction of talin with an integrin membrane-proximal region (MPR) that is critical for integrin activation. To test the functional significance of these...

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Identifiers

PMID: 24585775
DOI: 10.1182/blood-2013-12-543363
PMCID: PMC3999757

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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