Article
Recreation of the terminal events in physiological integrin activation.
The Journal of cell biology - 11 Jan 2010
Ye Feng, Hu Guiqing, Taylor Dianne, Ratnikov Boris, Bobkov Andrey A, McLean Mark A, Sligar Stephen G, Taylor Kenneth A, Ginsberg Mark H
Abstract excerpt
Increased affinity of integrins for the extracellular matrix (activation) regulates cell adhesion and migration, extracellular matrix assembly, and mechanotransduction. Major uncertainties concern the sufficiency of talin for activation, whether conformational change without clustering leads to activation, and whether mechanical force is required for molecular extension. Here, we reconstructed physiological...
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