Article
Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition.
Nature - 12 Dec 1991
Phillips R E, Rowland-Jones S, Nixon D F, Gotch F M, Edwards J P, Ogunlesi A O, Elvin J G, Rothbard J A, Bangham C R, Rizza C R
Abstract excerpt
In a longitudinal study of HIV seropositive patients, there were fluctuations in the specificity of cytotoxic T cells for the virus. This was matched by variability in proviral gag DNA epitope sequences in the lymphocytes of these patients. Some of these viral variants are not recognized by autol...
Topics
- Amino Acid Sequence
- Base Sequence
- Epitopes
- Genetic Variation
- HIV
- HIV Core Protein p24
- HIV Infections
- HIV Seropositivity
- Hemophilia A
- Humans
- Longitudinal Studies
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- T-Lymphocytes, Cytotoxic