Article
Lack of viral escape and defective in vivo activation of human immunodeficiency virus type 1-specific cytotoxic T lymphocytes in rapidly progressive infection.
Journal of virology - 1 Jul 1999
Hay C M, Ruhl D J, Basgoz N O, Wilson C C, Billingsley J M, DePasquale M P, D'Aquila R T, Wolinsky S M, Crawford J M, Montefiori D C, Walker B D
Abstract excerpt
Human immunodeficiency virus type 1 (HIV-1)-specific immune responses over the course of rapidly progressive infection are not well defined. Detailed longitudinal analyses of neutralizing antibodies, lymphocyte proliferation, in vivo-activated and memory cytotoxic T-lymphocyte (CTL) responses, and viral sequence variation were performed on a patient who presented with acute HIV-1 infection, developed an...
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