Article
Dynamics of HIV variants and specific cytotoxic T-cell recognition in nonprogressors and progressors.
Immunology letters - 1 Jun 1997
Haas G, Hosmalin A, Hadida F, Duntze J, Debré P, Autran B
Abstract excerpt
Infection with the human immunodeficiency virus (HIV) results in a disease characterized by a rapid viral replication, immunodeficiency and chronic immune activation. The vigorous polyspecific cytotoxic T-cell (CTL) response directed against multiple HIV epitopes reduces HIV-infected cell numbers, although unable to eradicate the virus. The plasticity of the specific CTL repertoire ensures adaptation to the high...
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