Article
Separase loss of function cooperates with the loss of p53 in the initiation and progression of T- and B-cell lymphoma, leukemia and aneuploidy in mice.
PloS one - 1 Jan 2011
Mukherjee Malini, Ge Gouqing, Zhang Nenggang, Huang Eryong, Nakamura Lanelle V, Minor Marissa, Fofanov Viacheslav, Rao Pullivarthi H, Herron Alan, Pati Debananda
Abstract excerpt
BACKGROUND: Cohesin protease Separase plays a key role in faithful segregation of sister chromatids by cleaving the cohesin complex at the metaphase to anaphase transition. Homozygous deletion of ESPL1 gene that encodes Separase protein results in embryonic lethality in mice and Separase overexpression lead to aneuploidy and tumorigenesis. However, the effect of Separase haploinsufficiency has not been thoroughly...
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