Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variations in dysfunction of sister chromatid cohesion in esco2 mutant zebrafish reflect the phenotypic diversity of Roberts syndrome.

Disease models & mechanisms - 1 Aug 2015

Percival Stefanie M, Thomas Holly R, Amsterdam Adam, Carroll Andrew J, Lees Jacqueline A, Yost H Joseph, Parant John M

Abstract excerpt

Mutations in ESCO2, one of two establishment of cohesion factors necessary for proper sister chromatid cohesion (SCC), cause a spectrum of developmental defects in the autosomal-recessive disorder Roberts syndrome (RBS), warranting in vivo analysis of the consequence of cohesion dysfunction. Through a genetic screen in zebrafish targeting embryonic-lethal mutants that have increased genomic instability, we have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetyltransferases
Share to Chromatids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ectromelia

Share to Embryo Loss

Share to Hypertelorism

Share to Mitotic Index

Share to Neural Tube

Share to Retroviridae

Source

Open in PubMed Open full text

Identifiers

PMID: 26044958
DOI: 10.1242/dmm.019059
PMCID: PMC4527282

Genes

ESCO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variations in dysfunction of sister chromatid cohesion in esco2 mutant zebrafish reflect the phenotypic diversity of Roberts syndrome.PMID 26044958Read ↗

Non-Redundant Roles in Sister Chromatid Cohesion of the DNA Helicase DDX11 and the SMC3 Acetyl Transferases ESCO1/2Semantic proximity Read ↗

The molecular mechanism underlying Roberts syndrome involves loss of ESCO2 acetyltransferase activity.Semantic proximity Read ↗

Roberts syndrome is caused by mutations in ESCO2, a human homolog of yeast ECO1 that is essential for the establishment of sister chromatid cohesionSemantic proximity Read ↗

Non-redundant roles in sister chromatid cohesion of the DNA helicase DDX11 and the SMC3 acetyl transferases ESCO1 and ESCO2.Semantic proximity Read ↗

A mutation in separase causes genome instability and increased susceptibility to epithelial cancer.Semantic proximity Read ↗

How many roads lead to cohesinopathies?Semantic proximity Read ↗

ROBERTS SYNDROME: CLINICAL AND CYTOGENETIC STUDIES IN 8 EGYPTIAN PATIENTS AND MOLECULAR STUDIES IN 4 PATIENTS WITH GENOTYPE/PHENOTYPE CORRELATION.Semantic proximity Read ↗

Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes.Semantic proximity Read ↗

Maternal Smc3 protects the integrity of the zygotic genome through DNA replication and mitosisSemantic proximity Read ↗

Cep57 is a cohesin-associated regulator of chromosome segregation, cell cycle progression and genome stability in early embryosSemantic proximity Read ↗

Establishment and characterization of Roberts syndrome and SC phocomelia model medaka (Oryzias latipes).Semantic proximity Read ↗

Cohesinopathies of a feather flock together.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.