Article

Cep57 is a cohesin-associated regulator of chromosome segregation, cell cycle progression and genome stability in early embryos

2025-04-16

Abstract excerpt

Faithful chromosome segregation and coordinated cell-cycle progression are essential for maintaining genome stability and preserving progenitor populations during vertebrate embryogenesis. Although pathogenic CEP57 variants are associated with developmental disorders including aneuploidy and microcephaly, the molecular mechanisms by which CEP57 coordinates these processes remain poorly understood. Here, we identif...

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Literature Corpus work: 8523a00d-6796-53fd-8090-ba0f564085a4
DOI: 10.1101/2025.04.10.648303

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