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Article

Genetic Identification of Separase Regulators in Caenorhabditis elegans.

G3 (Bethesda, Md.) - 2 Feb 2018

Melesse Michael, Sloan Dillon E, Benthal Joseph T, Caylor Quincey, Gosine Krishen, Bai Xiaofei, Bembenek Joshua N

Abstract excerpt

Separase is a highly conserved protease required for chromosome segregation. Although observations that separase also regulates membrane trafficking events have been made, it is still not clear how separase achieves this function. Here, we present an extensive ENU mutagenesis suppressor screen aimed at identifying suppressors of sep-1(e2406), a temperature-sensitive maternal effect embryonic lethal separase...

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Identifiers

PMID: 29246899
DOI: 10.1534/g3.117.300298
PMCID: PMC5919728

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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