Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Suppression of intestinal tumors by targeting the mitotic spindle of intestinal stem cells.

Oncogene - 24 Nov 2016

Yao R, Oyanagi J, Natsume Y, Kusama D, Kato Y, Nagayama S, Noda T

Abstract excerpt

Human colorectal cancer is often initiated by the aberrant activation of Wnt signaling, notably following adenomatous polyposis coli (Apc) inactivation. Recent studies identified adult intestinal stem cells (ISCs) and demonstrated their role as the cells of origin for intestinal tumors. However, the early consequences of aberrant Wnt signaling activation remain to be fully elucidated. Here, using organoid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenomatous Polyposis Coli Protein
Share to Fetal Proteins
Share to Gene Knockout Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intestinal Neoplasms

Share to Organoids

Share to Spindle Apparatus

Share to Tumor Burden

Share to Wnt Signaling Pathway

Source

Identifiers

PMID: 27157623
DOI: 10.1038/onc.2016.148

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suppression of intestinal tumors by targeting the mitotic spindle of intestinal stem cells.PMID 27157623Read ↗

Aneuploidy facilitates dysplastic and tumorigenic phenotypes in the Drosophila gut.Semantic proximity Read ↗

Wnt/β-Catenin Is Essential for Intestinal Homeostasis and Maintenance of Intestinal Stem CellsSemantic proximity Read ↗

Sox9 Induction, Ectopic Paneth Cells, and Mitotic Spindle Axis Defects in Mouse Colon Adenomatous Epithelium Arising From Conditional Biallelic Apc InactivationSemantic proximity Read ↗

Colorectal cancer stem cells.Semantic proximity Read ↗

Stem cells: the intestinal stem cell as a paradigmSemantic proximity Read ↗

Mitotic errors drive rapid clearance of polyploidy during intestinal regeneration despite robust centrosome clusteringSemantic proximity Read ↗

Human colon cancer stem cells: a new paradigm in gastrointestinal oncology.Semantic proximity Read ↗

Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue.Semantic proximity Read ↗

The tumor suppressor Apc controls planar cell polarities central to gut homeostasis.Semantic proximity Read ↗

A mutation in separase causes genome instability and increased susceptibility to epithelial cancer.Semantic proximity Read ↗

Aging restricts colorectal tumor growth by epigenetically silencing developmental gene programsSemantic proximity Read ↗

Aneuploidy promotes intestinal dysplasia in DrosophilaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.