Article
Ablation of Dido3 compromises lineage commitment of stem cells in vitro and during early embryonic development.
Cell death and differentiation - 1 Jan 2012
Fütterer A, Raya A, Llorente M, Izpisúa-Belmonte J C, de la Pompa J L, Klatt P, Martínez-A C
Abstract excerpt
The death inducer obliterator (Dido) locus encodes three protein isoforms, of which Dido3 is the largest and most broadly expressed. Dido3 is a nuclear protein that forms part of the spindle assembly checkpoint (SAC) and is necessary for correct chromosome segregation in somatic and germ cells. Here we report that specific ablation of Dido3 function in mice causes lethal developmental defects at the onset of...
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