Article
Clinicopathologic analysis of breast cancers with PIK3CA mutations in Japanese women.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2007
Maruyama Naomi, Miyoshi Yasuo, Taguchi Tetsuya, Tamaki Yasuhiro, Monden Morito, Noguchi Shinzaburo
Abstract excerpt
PURPOSE: Somatic mutations of PIK3CA, which encodes the p110alpha catalytic subunit of phosphatidylinositol 3-kinase, have recently been shown to play an important role in the pathogenesis and progression of human breast cancers. In this study, the frequency of PIK3CA mutations and their relationship with clinicopathologic and biological variables were investigated in Japanese breast cancers. EXPERIMENTAL DESIGN:...
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