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Article

The favorable impact of PIK3CA mutations on survival: an analysis of 2587 patients with breast cancer.

Chinese journal of cancer - 1 Jul 2012

Dumont Amaury G, Dumont Sarah N, Trent Jonathan C

Abstract excerpt

The phosphatidylinositol-3 kinase(PI3K) pathway regulates a number of cellular processes, including cell survival, cell growth, and cell cycle progression. Consequently, this pathway is commonly deregulated in cancer. In particular, mutations in the gene PIK3CA that encodes the p110α catalytic subunit of the PI3K enzymes result in cell proliferation and resistance to apoptosis in vitro and induce breast tumors in...

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Identifiers

PMID: 22640628
DOI: 10.5732/cjc.012.10032
PMCID: PMC3777497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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