Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PIK3CA mutations in breast cancer are associated with poor outcome.

Breast cancer research and treatment - 1 Mar 2006

Li Shao Ying, Rong Minna, Grieu Fabienne, Iacopetta Barry

Abstract excerpt

The phosphatidylinositol-3-kinase (PI3K)-AKT signaling pathway is considered to play an important role in tumorigenesis. Frequent somatic mutations in the PI3K subunit p110alpha (PIK3CA) occur in a variety of cancer types. We screened 250 primary human breast tumors for mutations in PIK3CA in order to determine associations with pathological features and with patient outcome. The frequency of PIK3CA mutations in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Ductal, Breast
Share to Cell Differentiation
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Invasiveness

Share to Phosphatidylinositol 3-Kinases

Share to Polymorphism, Single-Stranded Conformational

Share to Receptors, Estrogen

Share to Receptors, Progesterone

Source

Identifiers

PMID: 16317585
DOI: 10.1007/s10549-005-9048-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PIK3CA mutations in breast cancer are associated with poor outcome.PMID 16317585Read ↗

PIK3CA mutation associates with improved outcome in breast cancer.Semantic proximity Read ↗

The favorable impact of PIK3CA mutations on survival: an analysis of 2587 patients with breast cancer.Semantic proximity Read ↗

PI3K mutations in breast cancer: prognostic and therapeutic implicationsSemantic proximity Read ↗

The PIK3CA gene is mutated with high frequency in human breast cancersSemantic proximity Read ↗

PIK3CA mutations in breast cancerSemantic proximity Read ↗

PIK3CA gene mutation status associated with poor prognosis of breast cancer: a retrospective cohort studySemantic proximity Read ↗

Molecular evaluation of PIK3CA gene mutation in breast cancer: determination of frequency, distribution pattern and its association with clinicopathological findings in Indian patients.Semantic proximity Read ↗

PIK3CA-mutations in breast cancer.Semantic proximity Read ↗

Targeting PIK3CA Alterations in Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor-2-Negative Advanced Breast Cancer: New Therapeutic Approaches and Practical Considerations.Semantic proximity Read ↗

PIK3CA/AKT1 Mutations in Breast Carcinoma: a Comprehensive Review of Experimental and Clinical StudiesSemantic proximity Read ↗

Mutation distributions and clinical correlations of PIK3CA gene mutations in breast cancer.Semantic proximity Read ↗

Investigation of somatic PIK3CA gene mutations in breast cancer patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.