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Article

Analysis of PIK3CA Mutations and Activation Pathways in Triple Negative Breast Cancer.

PloS one - 1 Jan 2015

Cossu-Rocca Paolo, Orrù Sandra, Muroni Maria Rosaria, Sanges Francesca, Sotgiu Giovanni, Ena Sara, Pira Giovanna, Murgia Luciano, Manca Alessandra, Uras Maria Gabriela, Sarobba Maria Giuseppina, Urru Silvana, De Miglio Maria Rosaria

Abstract excerpt

BACKGROUND: Triple Negative Breast Cancer (TNBC) accounts for 12-24% of all breast carcinomas, and shows worse prognosis compared to other breast cancer subtypes. Molecular studies demonstrated that TNBCs are a heterogeneous group of tumors with different clinical and pathologic features, prognosis, genetic-molecular alterations and treatment responsivity. The PI3K/AKT is a major pathway involved in the...

Topics

Adult
Aged
Class I Phosphatidylinositol 3-Kinases
ErbB Receptors
Female
Genes, ras
Humans
Middle Aged
Mutation
PTEN Phosphohydrolase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphatidylinositol 3-Kinases

Proto-Oncogene Proteins B-raf

Proto-Oncogene Proteins c-akt

Signal Transduction

Triple Negative Breast Neoplasms

ras Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 26540293
DOI: 10.1371/journal.pone.0141763
PMCID: PMC4634768

Genes

BRAF
AKT1
EGFR
KRAS
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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