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Article

ATG16L1 rs2241880/T300A increases susceptibility to perianal Crohn's disease: An updated meta-analysis on inflammatory bowel disease risk and clinical outcomes.

United European gastroenterology journal - 1 Feb 2024

Simovic Isidora, Hilmi Ida, Ng Ruey Terng, Chew Kee Seang, Wong Shin Yee, Lee Way Seah, Riordan Stephen, Castaño-Rodríguez Natalia

Abstract excerpt

BACKGROUND: ATG16L1 plays a fundamental role in the degradative intracellular pathway known as autophagy, being a mediator of inflammation and microbial homeostasis. The variant rs2241880 can diminish these capabilities, potentially contributing to inflammatory bowel disease (IBD) pathogenesis. OBJECTIVES: To perform an updated meta-analysis on the association between ATG16L1 rs2241880 and IBD susceptibility by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37837511
DOI: 10.1002/ueg2.12477
PMCID: PMC10859713

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ATG16L1 rs2241880/T300A increases susceptibility to perianal Crohn's disease: An updated meta-analysis on inflammatory bowel disease risk and clinical outcomes.PMID 37837511Read ↗

T300A polymorphism of ATG16L1 and susceptibility to inflammatory bowel diseases: a meta-analysis.Semantic proximity Read ↗

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ATG16L1 T300A polymorphism and Crohn's disease susceptibility: evidence from 13,022 cases and 17,532 controls.Semantic proximity Read ↗

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