Article
In vivo determination of direct targets of the nonsense-mediated decay pathway in Drosophila.
G3 (Bethesda, Md.) - 20 Mar 2014
Chapin Alex, Hu Hao, Rynearson Shawn G, Hollien Julie, Yandell Mark, Metzstein Mark M
Abstract excerpt
Nonsense-mediated messenger RNA (mRNA) decay (NMD) is a mRNA degradation pathway that regulates a significant portion of the transcriptome. The expression levels of numerous genes are known to be altered in NMD mutants, but it is not known which of these transcripts is a direct pathway target. Here, we present the first genome-wide analysis of direct NMD targeting in an intact animal. By using rapid reactivation...
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