Nuclear localization is essential for the activity of p53 protein.

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Article

Nuclear localization is essential for the activity of p53 protein.

Oncogene - 1 Nov 1991

Shaulsky G, Goldfinger N, Tosky M S, Levine A J, Rotter V

Abstract excerpt

p53 appears to be a growth regulator, the perturbation of which induces changes in normal cell proliferation. Wild-type p53 protein is thought to function as a growth arrest gene, whereas mutant p53, which accumulates in transformed cells, has been shown to enhance malignant transformation. Both wild-type and mutant p53 migrate into the cell nucleus by means of identical nuclear localization signals (NLS)...

Topics

Amino Acid Sequence
Animals
Antigens, CD
Antigens, Differentiation, T-Lymphocyte
Base Sequence
Cell Nucleus
Cell Transformation, Neoplastic
Cells, Cultured
Chromosome Mapping
Epitopes
Fluorescent Antibody Technique

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, ras

Lectins, C-Type

Molecular Sequence Data

Mutation

Nuclear Localization Signals

Nuclear Proteins

Plasmids

Source

Open in PubMed

Identifiers

PMID: 1719467

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1719467-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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