Article
Defective nuclear localization of p53 protein in a Chinese hamster cell line is associated with the formation of stable cytoplasmic protein multimers in cells with gene amplification.
Carcinogenesis - 1 Sept 2000
Ottaggio L, Bozzo S, Moro F, Sparks A, Campomenosi P, Miele M, Bonatti S, Fronza G, Lane D P, Abbondandolo A
Abstract excerpt
Many p53 functions require p53 transport into the nucleus. Mutant p53 also generally accumulates in the nucleus of transformed or neoplastic cells. However, examples of cytoplasmic accumulation of wild-type or mutant p53 have also been reported. Various explanations have been provided for defective nuclear localization. Here we propose a novel example of cytoplasmic p53 localization which occurs in cells showing...
Topics
- 3T3 Cells
- Animals
- Antimetabolites, Antineoplastic
- Burkitt Lymphoma
- Cell Line, Transformed
- Cell Nucleus
- Cricetinae
- Cricetulus
- Cytoplasm
- DNA
- Dithiothreitol
- Drug Resistance, Neoplasm
- Gene Amplification