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Article

Wild-type p53 enhances efficiency of simian virus 40 large-T-antigen-induced cellular transformation.

Journal of virology - 1 Oct 2009

Hermannstädter Andrea, Ziegler Christine, Kühl Marion, Deppert Wolfgang, Tolstonog Genrich V

Abstract excerpt

Abortive infection of BALB/c mouse embryo fibroblasts differing in p53 gene status (p53(+/+) versus p53(-/)(-)) with simian virus 40 (SV40) revealed a quantitatively and qualitatively decreased transformation efficiency in p53(-/-) cells compared to p53(+/+) cells, suggesting a supportive effect of wild-type (wt) p53 in the SV40 transformation process. SV40 transformation efficiency also was low in immortalized...

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Source

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Identifiers

PMID: 19625393
DOI: 10.1128/JVI.00174-09
PMCID: PMC2748005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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