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Article

The transforming and suppressor functions of p53 alleles: effects of mutations that disrupt phosphorylation, oligomerization and nuclear translocation.

The EMBO journal - 1 Mar 1993

Slingerland J M, Jenkins J R, Benchimol S

Abstract excerpt

Mutant p53 alleles that have a recessive phenotype in human tumors can, in cooperation with an activated H-ras gene, transform rat embryo fibroblasts (REFs). Mutant p53 proteins differ from wild type, and from each other in conformation, localization and transforming potential. Missense mutations in codons 143, 175 and 275 confer strong transforming potential. A serine 135 p53 mutant has an intermediate...

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Identifiers

PMID: 8458321
DOI: 10.1002/j.1460-2075.1993.tb05744.x
PMCID: PMC413304

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The transforming and suppressor functions of p53 alleles: effects of mutations that disrupt phosphorylation, oligomerization and nuclear translocation.PMID 8458321Read ↗

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Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding.Semantic proximity Read ↗

Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression.Semantic proximity Read ↗

Mutant p53 tumor suppressor alleles release ras-induced cell cycle growth arrest.Semantic proximity Read ↗

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The properties of p53 proteins selected for the loss of suppression of transformation.Semantic proximity Read ↗

p53 must be competent for transcriptional regulation to suppress tumor formation.Semantic proximity Read ↗

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