Diuretic-gene interaction and the risk of myocardial infarction and stroke.

doi:10.1038/sj.tpj.6500428

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Article

Diuretic-gene interaction and the risk of myocardial infarction and stroke.

The pharmacogenomics journal - 1 Oct 2007

Schelleman H, Klungel O H, Witteman J C M, Breteler M M B, Hofman A, van Duijn C M, de Boer A, Stricker B H Ch

Abstract excerpt

This study investigates whether the interaction between diuretics and alpha-adducin (ADD1) G460W or G-protein beta3-subunit (GNB3) rs2301339 polymorphism modifies the risk of myocardial infarction (MI) or stroke. Data were used from the Rotterdam Study. The drug-gene interaction was determined with a Cox proportional hazard model with adjustment for each drug class as time-dependent covariates. The risk of MI in...

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Identifiers

PMID: 17189961
DOI: 10.1038/sj.tpj.6500428

Genes

ADD1
GNB3

Variants

rs2301339

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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