Article
Effectiveness of statins in the reduction of the risk of myocardial infarction is modified by the GNB3 C825T variant.
Pharmacogenetics and genomics - 1 Jul 2008
Peters Bas J M, Maitland-van der Zee Anke-Hilse, Stricker Bruno H Ch, van Wieren-de Wijer Diane B M A, de Boer Anthonius, Kroon Abraham A, de Leeuw Peter W, Schiffers Paul, Janssen Rob G J H, van Duijn Cornelia M, Klungel Olaf H
Abstract excerpt
INTRODUCTION: The GNB3 C825T polymorphism has been shown to affect lipid parameters, atherosclerosis progression, and incidence of myocardial infarction (MI). Therefore, we assessed whether the effectiveness of statins in reducing the risk of MI was modified by the GNB3 C825T polymorphism. METHODS: In a population-based registry of pharmacy records linked to hospital discharge records (PHARMO), we used a nested...
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