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Article

Associations between antihypertensive drug-related gene polymorphisms and cardiovascular outcomes in hypertensive patients: a gene-drug interaction study.

Scientific reports - 12 Apr 2026

Li Zetong, Liu Huixia, Chen Mengshi, Deng Jing, Ma Ziyu, Huang Ge, Li Cheng, Su Meng, Zhong Hua

Abstract excerpt

Antihypertensive therapy is pivotal in preventing cardiovascular events, yet treatment efficacy varies significantly among individuals due to genetic polymorphisms.This study aimed to investigate the association between specific antihypertensive drug-related gene polymorphisms, the use of corresponding sensitive drugs, and the risks of stroke and coronary heart disease (CHD) in a community-based hypertensive...

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Topics

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Share to Antihypertensive Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C9

Share to Cytochrome P-450 CYP2D6

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Share to Receptor, Angiotensin, Type 1

Share to Receptors, Adrenergic, beta-1

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Source

Open in PubMed Open full text

Identifiers

PMID: 41968188
DOI: 10.1038/s41598-026-48528-w
PMCID: PMC13230963

Genes

AGTR1
ADRB1
CYP3A5
NPPA
ACE
CYP2C9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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