Article
beta1- and beta2-adrenergic receptor gene variation, beta-blocker use and risk of myocardial infarction and stroke.
American journal of hypertension - 1 Mar 2008
Lemaitre Rozenn N, Heckbert Susan R, Sotoodehnia Nona, Bis Joshua C, Smith Nicholas L, Marciante Kristin D, Hindorff Lucia A, Lange Leslie A, Lumley Thomas S, Rice Kenneth M, Wiggins Kerri L, Psaty Bruce M
Abstract excerpt
BACKGROUND: The benefits of beta-blocker therapy may depend on underlying genetic susceptibility. METHODS: We investigated the interaction of common variation in beta1 and beta2 adrenergic receptor (AR) genes with beta-blocker use on the risks of myocardial infarction (MI) and ischemic stroke in a case-control study. Participants were treated pharmacologically for hypertension, aged 30-79 years, with incident MI...
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