Article
Alpha-adducin polymorphism associated with increased risk of adverse cardiovascular outcomes: results from GENEtic Substudy of the INternational VErapamil SR-trandolapril STudy (INVEST-GENES).
American heart journal - 1 Aug 2008
Gerhard Tobias, Gong Yan, Beitelshees Amber L, Mao Xianyun, Lobmeyer Maximilian T, Cooper-DeHoff Rhonda M, Langaee Taimour Y, Schork Nicholas J, Shriver Mark D, Pepine Carl J, Johnson Julie A
Abstract excerpt
BACKGROUND: The alpha-adducin (ADD1) Gly460Trp polymorphism has been associated with hypertension and response to diuretic therapy, but controversy exists. METHODS: The present study was conducted to prospectively investigate the relationship among the ADD1 Gly460Trp polymorphism, diuretic use, and adverse cardiovascular outcomes among 5,979 patients with hypertensive coronary artery disease, who participated in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.