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Article

Angiotensin-converting enzyme I/D and alpha-adducin Gly460Trp polymorphisms: from angiotensin-converting enzyme activity to cardiovascular outcome.

Hypertension (Dallas, Tex. : 1979) - 1 Jun 2007

Li Yan, Zagato Laura, Kuznetsova Tatiana, Tripodi Grazia, Zerbini Gianpaolo, Richart Tom, Thijs Lutgarde, Manunta Paolo, Wang Ji-Guang, Bianchi Giuseppe, Staessen Jan A

Abstract excerpt

The angiotensin-converting enzyme (ACE) I/D and the alpha-adducin (ADD1) Gly460Trp polymorphisms are associated with cardiovascular risk factors. In a prospective population study and in cell models, we investigated the combined effects of these 2 polymorphisms. We randomly recruited 1287 white subjects (women: 50.0%; mean age: 55.9 years). We obtained outcomes from registries and repeat examinations (median 3)....

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Source

Identifiers

PMID: 17452507
DOI: 10.1161/HYPERTENSIONAHA.106.085498

Genes

ADD1
ACE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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