Article
Angiotensinogen M235T polymorphism and the risk of myocardial infarction and stroke among hypertensive patients on ACE-inhibitors or beta-blockers.
European journal of human genetics : EJHG - 1 Apr 2007
Schelleman Hedi, Klungel Olaf H, Witteman Jacqueline C M, Breteler Monique M B, Yazdanpanah Moygan, Danser A H Jan, Hofman Albert, van Duijn Cornelia M, de Boer Anthonius, Stricker Bruno H Ch
Abstract excerpt
Angiotensinogen is an essential component of the renin-angiotensin system. ACE-inhibitors and beta-blockers both have a direct influence on this system. To investigate whether the association between use of ACE-inhibitors or beta-blockers and the risk of myocardial infarction (MI) or stroke is modified by the T-allele of the angiotensinogen M235T polymorphism. In this study, 4097 subjects with hypertension , aged...
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