Article
GNAS1 (Gαs) gene T393C polymorphism and renal cell carcinoma risk in a North Indian population: a case-control study.
Genetic testing and molecular biomarkers - 1 Sept 2012
Arjumand Wani, Ahmad Shiekh Tanveer, Nafees Sana, Ali Nemat, Rashid Summya, Seth Amlesh, Sultana Sarwat
Abstract excerpt
AIM: Heterotrimeric G protein α-subunit Gαs is required for activation of adenylyl cyclase and generation of cyclic adenosine monophosphate (cAMP) in cells and plays a key role in multiple signal transduction pathways, linked to proapoptotic processes in cancer cells. This study investigated whether Gαs gene polymorphism was associated with increased renal cell carcinoma (RCC) risk in the North Indian population....
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