Article
The GNAS1 T393C polymorphism predicts survival in patients with advanced squamous cell carcinoma of the larynx.
The Laryngoscope - 1 Dec 2008
Lehnerdt Goetz F, Franz Peter, Winterhoff Sebastian, Bankfalvi Agnes, Grehl Sara, Lang Stephan, Schmid Kurt W, Siffert Winfried, Jahnke Klaus, Frey Ulrich H
Abstract excerpt
OBJECTIVES/HYPOTHESIS: In previous studies, we have demonstrated that the T-allele of a specific single nucleotide polymorphism (SNP) in the Galphas gene (T393C) correlates with increased Galphas expression and hence apoptosis. The T-allele was associated with a favorable outcome in a variety of human cancers, for example, carcinoma of the urinary bladder, kidney, colorectal, oro- and hypopharynx. STUDY DESIGN:...
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