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Article

Retinoic acid-induced glandular differentiation of the oesophagus.

Gut - 1 Jul 2007

Chang Chih-Long, Lao-Sirieix Pierre, Save Vicki, De La Cueva Mendez Guillermo, Laskey Ron, Fitzgerald Rebecca C

Abstract excerpt

BACKGROUND: Retinoic acid (RA) is a powerful differentiation agent. Barrett's oesophagus occurs when duodeno-gastro-oesophageal reflux causes squamous epithelium (SE) tissue to become columnar epithelium tissue by an unknown mechanism. The bile acid lithocholic acid (LCA) competes for the retinoid X receptor retinoid binding site. Hence, RA pathways may be implicated in Barrett's oesophagus. METHODS: RA activity...

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Source

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Identifiers

PMID: 17185354
DOI: 10.1136/gut.2006.097915
PMCID: PMC1994378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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