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Article

Barrett's metaplasia develops from cellular reprograming of esophageal squamous epithelium due to gastroesophageal reflux.

American journal of physiology. Gastrointestinal and liver physiology - 1 Jun 2017

Minacapelli Carlos D, Bajpai Manisha, Geng Xin, Cheng Christina L, Chouthai Abhishek A, Souza Rhonda, Spechler Stuart J, Das Kiron M

Abstract excerpt

Gastroesophageal reflux disease (GERD) clinically predisposes to columnar Barrett's metaplasia (BM) in the distal esophagus. We demonstrate evidence supporting the cellular origin of BM from reprograming or transcommitment of resident normal esophageal squamous (NES) epithelial cells in response to acid and bile (A + B) exposure using an in vitro cell culture model. The hTERT-immortalized NES cell line NES-B10T...

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Source

Identifiers

PMID: 28336546
DOI: 10.1152/ajpgi.00268.2016

Genes

NES
CDX2
SOX9

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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