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Article

Repeated exposure to acid and bile selectively induces colonic phenotype expression in a heterogeneous Barrett's epithelial cell line.

Laboratory investigation; a journal of technical methods and pathology - 1 Jun 2008

Bajpai Manisha, Liu Jianying, Geng Xin, Souza Rhonda F, Amenta Peter S, Das Kiron M

Abstract excerpt

Barrett's epithelium is a precancerous, specialized columnar metaplasia in the distal esophagus. We demonstrate the changes in cellular phenotype in a non-neoplastic Barrett's cell line (BAR-T), following exposure to acid and bile salt, the two important components of gastroesophageal refluxate. Cell phenotypes in BAR-T cell line were quantified by fluorescence-activated cell sorting (FACS) using monoclonal...

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Identifiers

PMID: 18427553
DOI: 10.1038/labinvest.2008.34

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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