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Article

Retinoic acid signaling drives differentiation toward the absorptive lineage in colorectal cancer

15 Nov 2021

Abstract excerpt

Retinoic acid (RA) signaling is an important and conserved pathway that regulates cellular proliferation and differentiation. Furthermore, perturbed RA signaling is implicated in cancer initiation and progression. However, the mechanisms by which RA signaling contributes to homeostasis, malignant transformation, and disease progression in the intestine remain incompletely understood. Here, we report, in agreement...

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PMID: 34877501
DOI: 10.1016/j.isci.2021.103444

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