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Article

Activating killer cell immunoglobulin-like receptor 2DS2 binds to HLA-A*11

3 Feb 2014

Abstract excerpt

Inhibitory killer cell Ig-like receptors (KIRs) are known to recognize HLA ligands mainly of the HLA-C and Bw4 groups, but the ligands for KIRs are poorly understood. We report here the identification of the cognate ligand for the activating KIR 2DS2 as HLA-A*11:01. The crystal structure of the KIR2DS2-HLA-A*11:01 complex was solved at 2.5-Å resolution and revealed residue-binding characteristics distinct from...

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PMID: 24550293
DOI: 10.1073/pnas.1322052111

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