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Article

Geminin prevents rereplication during xenopus development.

The Journal of biological chemistry - 23 Feb 2007

Kerns Sarah L, Torke Susanna J, Benjamin Jacqueline M, McGarry Thomas J

Abstract excerpt

To maintain a stable genome, it is essential that replication origins fire only once per cell cycle. The protein Geminin is thought to prevent a second round of DNA replication by inhibiting the essential replication factor Cdt1. Geminin also affects the development of several different organs by binding and inhibiting transcription factors and chromatin-remodeling proteins. It is not known if the defects in...

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Source

Identifiers

PMID: 17179155
DOI: 10.1074/jbc.M609289200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Geminin prevents rereplication during xenopus development.PMID 17179155Read ↗

Geminin is required for zygotic gene expression at the Xenopus mid-blastula transition.Semantic proximity Read ↗

Geminin deficiency causes a Chk1-dependent G2 arrest in Xenopus.Semantic proximity Read ↗

Geminin is essential for the development of preimplantation mouse embryosSemantic proximity Read ↗

Loss of Geminin induces rereplication in the presence of functional p53Semantic proximity Read ↗

Repression of nascent strand elongation by deregulated Cdt1 during DNA replication in Xenopus egg extracts.Semantic proximity Read ↗

Cdt1 and Cdc6 are destabilized by rereplication-induced DNA damage.Semantic proximity Read ↗

Selective Killing of Cancer Cells by Suppression of Geminin ActivitySemantic proximity Read ↗

Depletion of licensing inhibitor geminin causes centrosome overduplication and mitotic defects.Semantic proximity Read ↗

Caenorhabditis elegans geminin homologue participates in cell cycle regulation and germ line development.Semantic proximity Read ↗

Rereplication by Depletion of Geminin Is Seen Regardless of p53 Status and Activates a G<sub>2</sub>/M CheckpointSemantic proximity Read ↗

GMNN mutations cause female infertility characterized by preimplantation embryo arrest through regulating DNA re-replication.Semantic proximity Read ↗

Levels of the origin-binding protein Double parked and its inhibitor Geminin increase in response to replication stress.Semantic proximity Read ↗

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