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Article

Geminin is essential for the development of preimplantation mouse embryos

29 Sept 2006

Abstract excerpt

Replication of DNA is strictly controlled to ensure that it occurs only once per cell cycle. Geminin has been thought to serve as a central mediator of this licensing mechanism by binding to and antagonizing the function of Cdt1 and thereby preventing re-replication during S and G2 phases. We have now generated mice deficient in geminin to elucidate the physiologic role of this protein during development. Lack of...

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Identifiers

PMID: 17054725
DOI: 10.1111/j.1365-2443.2006.01019.x

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Related research

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Geminin is essential for the development of preimplantation mouse embryosPMID 17054725Read ↗

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Geminin prevents rereplication during xenopus development.Semantic proximity Read ↗

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Depletion of licensing inhibitor geminin causes centrosome overduplication and mitotic defects.Semantic proximity Read ↗

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