Article
GMNN mutations cause female infertility characterized by preimplantation embryo arrest through regulating DNA re-replication.
Science China. Life sciences - 1 Aug 2025
Zhang Honghui, Su Wei, Jiang Xiaohong, Wang Yang, Yang Bohan, Wan Xian, Li Cheng, Zhao Shuai, Zhang Changlong, Zhao Shigang, Bian Yuehong, Li Mei, Wu Keliang, Gong Fei, Lin Ge, Zheng Wei, Zhao Han, Chen Zi-Jiang
Abstract excerpt
Preimplantation embryo arrest is a common cause of female infertility and recurrent failure of assisted reproductive technology. However, its genetic basis is largely unrevealed. Geminin, encoded by the GMNN gene, plays an important role in preventing DNA re-replication by inhibiting CDT1. Here, using whole-exome sequencing and Sanger sequencing, we identified three rare missense mutations of GMNN in females with...
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