Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Geminin deficiency causes a Chk1-dependent G2 arrest in Xenopus.

Molecular biology of the cell - 1 Oct 2002

McGarry Thomas J

Abstract excerpt

Geminin is an unstable inhibitor of DNA replication that gets destroyed at the metaphase/anaphase transition. The biological function of geminin has been difficult to determine because it is not homologous to a characterized protein and has pleiotropic effects when overexpressed. Geminin is thought to prevent a second round of initiation during S or G2 phase. In some assays, geminin induces uncommitted embryonic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to G2 Phase
Share to CDC2 Protein Kinase
Share to cdc25 Phosphatases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Checkpoint Kinase 1

Share to Embryo, Nonmammalian

Share to Oligonucleotides, Antisense

Share to Xenopus laevis

Share to Xenopus Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 12388764
DOI: 10.1091/mbc.e02-04-0199
PMCID: PMC129973

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Geminin deficiency causes a Chk1-dependent G2 arrest in Xenopus.PMID 12388764Read ↗

Geminin prevents rereplication during xenopus development.Semantic proximity Read ↗

Geminin is required for zygotic gene expression at the Xenopus mid-blastula transition.Semantic proximity Read ↗

Rereplication by Depletion of Geminin Is Seen Regardless of p53 Status and Activates a G<sub>2</sub>/M CheckpointSemantic proximity Read ↗

Geminin is essential for the development of preimplantation mouse embryosSemantic proximity Read ↗

Loss of Geminin induces rereplication in the presence of functional p53Semantic proximity Read ↗

GMNN mutations cause female infertility characterized by preimplantation embryo arrest through regulating DNA re-replication.Semantic proximity Read ↗

Caenorhabditis elegans geminin homologue participates in cell cycle regulation and germ line development.Semantic proximity Read ↗

Depletion of licensing inhibitor geminin causes centrosome overduplication and mitotic defects.Semantic proximity Read ↗

Direct interaction of geminin and Six3 in eye development.Semantic proximity Read ↗

Geminin ablation in vivo enhances tumorigenesis through increased genomic instability.Semantic proximity Read ↗

Selective Killing of Cancer Cells by Suppression of Geminin ActivitySemantic proximity Read ↗

Geminin loss causes neural tube defects through disrupted progenitor specification and neuronal differentiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.